Restylane Defyne for Chin Contouring: What Clinical Studies Show
When it comes to facial harmony, the chin plays a bigger role than many people realize. A well-defined chin anchors the face, balances the nose and jawline, and creates a sense of symmetry that instantly looks more youthful and refined. For patients with a naturally recessed chin, or those noticing age-related softening, injectable chin fillers have become an increasingly popular alternative to surgery.
Among the available options, Restylane® Defyne has gained attention not only for its ability to smooth deep facial folds but also for its FDA-approved use in chin augmentation and contouring. But how effective is it really? Let’s take a closer look at what clinical studies reveal about Restylane Defyne for the chin.
What Is Restylane Defyne?
Restylane Defyne is a hyaluronic acid (HA) dermal filler formulated with a unique crosslinking technology known as XpresHAn™ Technology. This design makes the filler strong enough to provide structural support while still allowing natural flexibility and movement. In practical terms, this means the filler can both lift and contour while adapting to facial expressions, ideal for dynamic areas like the lower face.
Defyne is FDA-approved not only for smoothing deep nasolabial folds (the “smile lines” around the mouth) but also for chin augmentation in adults over 21. This expands its role from wrinkle correction to true facial balancing and contouring.
The Pivotal Chin Study
A large, randomized, multicenter, evaluator-blinded clinical study was conducted to specifically evaluate Restylane Defyne for chin augmentation. Here are the key details:
Subjects: 140 adults, ages 20–73, with mild to moderate chin retrusion (a recessed or under-projected chin).
Design: Participants were randomized to either receive Restylane Defyne or serve as no-treatment controls. A touch-up treatment was allowed after 4 weeks if optimal correction wasn’t achieved.
Follow-Up: Patients were followed for up to 48 weeks after treatment.
Effectiveness Results
The results were clear:
At 12 weeks, 81.3% of treated patients were rated as responders (at least a one-grade improvement on the Galderma Chin Retrusion Scale), compared with just 6.1% in the no-treatment group.
Improvements were maintained throughout the study, with significant response rates seen at 24, 36, and even 48 weeks post-treatment.
Patient satisfaction was high, with FACE-Q questionnaires showing greater satisfaction with chin appearance in the Restylane group compared to controls.
Investigators also reported that 96–100% of treated patients showed aesthetic improvement at follow-ups.
This durability, lasting close to a year, is consistent with what patients typically expect from HA fillers in high-movement areas.
Safety Profile
Safety was a major component of the study. Reported injection-related events included:
Tenderness, pain, swelling, and lumps/bumps (the most common side effects).
Most side effects were mild or moderate and resolved within 1–3 weeks.
A small percentage experienced temporary redness or bruising.
No treatment-related serious adverse events were reported.
Importantly, chin function and sensation were assessed at every visit, and all subjects maintained normal movement and sensation post-treatment. This reassures patients that chin mobility is preserved.
How Restylane Defyne Works in Chin Contouring
What makes Defyne unique for chin augmentation is its balance of support and flexibility. Unlike some fillers that may feel too rigid or create unnatural results, Defyne’s formulation integrates smoothly with tissue. Clinically, this allows providers to:
Project the chin forward for patients with natural retrusion.
Refine the chin shape, creating more symmetry and harmony with the rest of the face.
Soften the pre-jowl area, improving jawline contour in patients starting to see age-related volume loss.
Enhance overall facial balance without the downtime of surgery.
Because the filler adapts to movement, patients can still smile, talk, and eat without the chin appearing stiff or “overdone.”
What Patients Can Expect
Procedure time: Typically 15–30 minutes.
Comfort: The product contains lidocaine for comfort during injection. Most patients describe the experience as tolerable.
Recovery: Mild swelling or bruising may last a few days. Makeup and normal activities can usually resume within 24 hours.
Longevity: Clinical results last about 12 months in most patients, after which retreatment is recommended.
How It Compares to Surgery
For patients considering chin implants or surgical genioplasty, Restylane Defyne offers an appealing non-surgical alternative:
No incisions or general anesthesia.
Reversible, since HA fillers can be dissolved with hyaluronidase.
Allows patients to “test drive” a new chin profile before committing to permanent surgery.
That said, for patients with severe chin retrusion or skeletal imbalances, surgery may still be the more powerful option. Fillers are best for mild to moderate contouring.
Clinical Takeaways
Based on published studies, Restylane Defyne has proven to be:
Safe and effective for chin augmentation.
Capable of delivering natural-looking results that last close to a year.
A treatment with high patient satisfaction and minimal downtime.
Work with Chin Filler Experts in Redondo Beach
Restylane Defyne isn’t just another wrinkle filler, it’s a scientifically validated option for reshaping one of the face’s most defining features: the chin. Clinical studies show it reliably improves chin projection, contour, and overall facial harmony, with results that are both natural and durable.
For anyone hesitant about surgery but eager to balance their profile or sharpen their jawline, Restylane Defyne offers a compelling, non-surgical path forward.
Contact the medical experts at Beauty Cult today for a consultation.
